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December 1, 1972The Journal of PhysiologyOpen Access

Membrane current and contraction in frog atrial fibres

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Population

Short segments of frog atrial muscle strips

Comparison

Depolarizations of varying durations using a… vs Normal Ringer fluid / baseline conditions

Design

Preclinical

Authors

HEH. M. EinwächterHeidelberg UniversityHHHans HaasOstalb-Klinikum AalenRKRichard A. KernUniversity of California, Berkeley

Discussion

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Implication

Distinguishes phasic from tonic calcium sources in frog atrium; leaves open translation to mammalian cardiac physiology.

Structured PICO

P
Population
Short segments of frog atrial muscle strips
I
Intervention
Depolarizations of varying durations (short-lasting vs long-lasting) using a double sucrose gap voltage clamp arrangement, removal of Ca ions, and application of a 'Ca inhibitor'
C
Comparator
Normal Ringer fluid / baseline conditions
O
Outcome
Membrane current (I(Ca)) and mechanical activity (phasic and tonic contractions)surrogate

In frog atrial muscle, phasic contractions are directly activated by inward calcium current, while tonic contractions rely on a distinct calcium mechanism.

Cite This Study

Einwächter et al. (1972) studied this question.

synapsesocial.com/papers/6a77d688df493903fd1f426ehttps://doi.org/10.1113/jphysiol.1972.sp010024
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The dependence of the contractile force generated by frog auricular trabeculae upon the external calcium concentration1971 · 39 citations
  2. 2A STUDY ON THE EXCITATION-CONTRACTION COUPLING OF THEBULLFROG VENTRICLE WITH VOLTAGE CLAMP TECHNIQUE1971 · 36 citations
  3. 3Effects of calcium on the contraction of the hypodynamic frog heart1970 · 56 citations
  4. 4Inotropic Effects of Electric Currents1969 · 305 citations
  5. 5Studies of Cardiac Muscle with a High Permeability to Calcium Produced by Treatment with Ethylenediaminetetraacetic Acid1971 · 139 citations