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January 1, 1993Clinical and Experimental Hypertension

Changes in Extracellular Ca2+Over a Physiologic Concentration Range Differentially Modulate Reactivity of Resistance Arteries of Spontaneously Hypertensive and Normotensive Rats

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Key result

Alterations in extracellular Ca2+ enhanced sensitivity to norepinephrine in spontaneously hypertensive rats and endothelium-denuded normotensive rats.

Population

Mesenteric resistance arteries of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats

Comparison

Exposure to varying extracellular Ca2+… vs 1.5 mM Ca2+ concentration and normotensive WKY…

Design

Preclinical

Authors

JLJunyi LiTianjin University of Traditional Chinese MedicineLELorna K. EhrenfriedThe University of Texas Medical Branch at GalvestonRBRichard D. BukoskiNorth Carolina Central University

Discussion

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Implication

Endothelial protection against Ca2+-driven norepinephrine hyperreactivity appears lost in hypertension models; leaves open human relevance and therapeutic targeting.

Structured PICO

P
Population
Mesenteric resistance arteries of normotensive Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats
I
Intervention
Exposure to varying extracellular Ca2+ concentrations (1.25, 1.5, and 2.5 mM) and norepinephrine
C
Comparator
1.5 mM Ca2+ concentration and normotensive WKY vessels
O
Outcome
Norepinephrine-induced contractile responsessurrogate

The endothelium of normotensive rats protects against calcium-induced changes in sensitivity to norepinephrine, a protective mechanism that is absent in spontaneously hypertensive rats.

Cite This Study

Li et al. (1993) studied Hypertension. Extracellular Ca2+ concentration changes vs. 1.5 mM Ca2+ was evaluated on Norepinephrine-induced contractile responses of mesenteric resistance arteries. Alterations in extracellular Ca2+ enhanced sensitivity to norepinephrine in spontaneously hypertensive rats and endothelium-denuded normotensive rats.

synapsesocial.com/papers/6a24ae1fef83ecbb390c198ehttps://doi.org/10.3109/10641969309041646

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve cyclooxygenase pathway1990 · 182 citations
  2. 2Mechanisms of calcium relaxation of vascular smooth muscle1991 · 26 citations
  3. 3Vascular Smooth Muscle: Dual Effect of Calcium1963 · 285 citations
  4. 4Role of endothelium in dilator responses of spontaneously hypertensive rat arteries.1983 · 411 citations
  5. 5Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.1990 · 3,307 citations