Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 1, 1981Experimental Biology and Medicine

Calcium Modulation of Microvascular Sensitivity during Renovascular Hypertension

View Full Paper
Ask AI
Bookmark
Share

Population

Normotensive and one-kidney, one-clip Goldblatt hypertensive rats

Comparison

In vivo alterations in local calcium… vs Normotensive rats vs hypertensive rats; varying…

Design

Preclinical

Authors

IJIrving G. JoshuaUniversity of LouisvillePHPeter HarrisPfizer (United States)DWDavid L. WiegmanUniversity of Louisville

Discussion

Loading...

Member takes

Implication

Attenuated Ca²⁺ modulation of vasoconstriction in hypertensive arterioles warrants clinical caution; leaves open mechanistic targets for human hypertension research.

Structured PICO

P
Population
Normotensive and one-kidney, one-clip Goldblatt hypertensive rats
I
Intervention
In vivo alterations in local calcium concentration (1.3, 2.6, or 5.1 mM CaCl2) in modified Krebs solution
C
Comparator
Normotensive rats vs hypertensive rats; varying calcium concentrations
O
Outcome
Small vessel responses to norepinephrine (lumenal diameters and norepinephrine sensitivity pD2)surrogate

Mechanisms for calcium modulation of vasoconstriction are attenuated in large arterioles of one-kidney, one-clip Goldblatt hypertensive rats.

Cite This Study

Joshua et al. (1981) studied this question.

synapsesocial.com/papers/6a902b95d30595a0c64dc9d5https://doi.org/10.3181/00379727-167-41194
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1In VIVO Arteriolar Reactivity to Norepinephrine and Calcium in One-Kidney, One-Clip Goldblatt Hypertensive Rats1987 · 3 citations
  2. 2Microvascular responses to norepinephrine in renovascular and spontaneously hypertensive rats1979 · 18 citations
  3. 3Norepinephrine-induced calcium signaling pathways in afferent arterioles of genetically hypertensive rats2001 · 32 citations
  4. 4Changes in Extracellular Ca<sup>2+</sup>Over a Physiologic Concentration Range Differentially Modulate Reactivity of Resistance Arteries of Spontaneously Hypertensive and Normotensive Rats1993 · 8 citations
  5. 5<u>In vivo</u>Venular Changes with the Development of One-Kidney, one-Clip Hypertension in the Rat1986 · 1 citations