Population
Male and female spontaneously hypertensive rats and sex and weight matched normotensive Kyoto Wistar and…
Comparison
Renal nerve stimulation and administration of… vs Sex and weight matched normotensive Kyoto Wistar…
Design
Preclinical
Authors
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Renal vascular supersensitivity may contribute to SHR hypertension; leaves open relevance to human disease.
Renal vessels of spontaneously hypertensive rats exhibit supersensitivity to receptor-stimulating agonists and impaired relaxation, suggesting an inherent defect in renal vascular reactivity that may contribute to hypertension.
Collis et al. (1977) studied this question.
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