What question did this study set out to answer?

Determine whether renin induces blood pressure elevation through local vascular generation of angiotensin II by evaluating the effects of circulating antiserum versus a low-molecular-weight antagonist.

February 1, 1974Clinical Science

Action of Angiotensin Antagonists and Antiserum upon the Pressor Response to Renin: Further Evidence for the Local Generation of Angiotensin II

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Why the study?

Does angiotensin II antagonist or antiserum alter the pressor response to renin in bilaterally nephrectomized rats?

Population

Bilaterally nephrectomized rats

Design

Preclinical

Authors

HTH. ThurstonUniversity Hospitals of Leicester NHS Trust JSJ. D. SwalesGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Does not alter clinical hypertension management; leaves open local vascular angiotensin II relevance in humans.

Key Points

Determine whether renin induces blood pressure elevation through local vascular generation of angiotensin II by evaluating the effects of circulating antiserum versus a low-molecular-weight antagonist.
Infused pressor doses of renin into bilaterally nephrectomized rats either before or following pretreatment with angiotensin II antiserum.
Administered the low-molecular-weight angiotensin II antagonist 1-sarcosine-8-alanine angiotensin II to test its capacity to normalize blood pressure.
Angiotensin II antiserum only partially normalized blood pressure after renin infusion, and antiserum-pretreated rats still mounted a pressor response.
Infusion of 1-sarcosine-8-alanine angiotensin II fully restored blood pressure to normal baseline levels in both groups of rats.

Structured PICO

Does angiotensin II antagonist or antiserum alter the pressor response to renin in bilaterally nephrectomized rats?

Population

Bilaterally nephrectomized rats

Intervention

Angiotensin II antiserum and/or angiotensin II antagonist (1-sarcosine-8-alanine angiotensin II)

Outcome

Pressor response (blood pressure)surrogate

The study provides evidence that renin generates angiotensin II at a local vascular level, which is accessible to low-molecular-weight antagonists but not to antisera.

Cite This Study

Thurston et al. (1974) studied this question.

synapsesocial.com/papers/6a840e78064c65267cc6b660 https://doi.org/10.1042/cs0460273

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Action of Angiotensin Antagonists and Antiserum upon the Pressor Response to Renin: Further Evidence for the Local Generation of Angiotensin II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Action of Angiotensin Antagonists and Antiserum upon the Pressor Response to Renin: Further Evidence for the Local Generation of Angiotensin II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider