What question did this study set out to answer?

To investigate whether angiotensin II mediates the exaggerated pressor response to norepinephrine infusion during the early prehypertensive phase of renal artery stenosis.

January 1, 1984Kitakantou igaku/Kitakantō IgakuOpen Access

Comparative Effect of Two Different Angiotessin Ii

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Why the study?

Do angiotensin II antagonists reduce the exaggerated pressor response to norepinephrine in rabbits with renal artery stenosis?

Key Points

To investigate whether angiotensin II mediates the exaggerated pressor response to norepinephrine infusion during the early prehypertensive phase of renal artery stenosis.
Evaluated vascular pressor responses to norepinephrine infusion in rabbits with 3-day one-kidney, one-clip Goldblatt renal artery stenosis versus sham-operated controls.
Infused two distinct angiotensin II antagonists varying at position 8 ([1-Sar, 8-Ileu] angiotensin II and [1-Sar, 8-Ara] angiotensin II) during norepinephrine challenge.
Measured baseline blood pressure and plasma renin activity (PRA) to assess correlations with vascular responsiveness.
Three-day clipped rabbits demonstrated an exaggerated pressor response to norepinephrine despite maintaining normal baseline blood pressure and normal plasma renin activity.
Infusion of either [1-Sar, 8-Ileu] or [1-Sar, 8-Ara] angiotensin II completely abolished the exaggerated pressor response to norepinephrine.
No correlation occurred between plasma renin activity and the magnitude of pressor hyperresponsiveness to norepinephrine, indicating potential involvement of additional vascular mechanisms.

Structured PICO

Do angiotensin II antagonists reduce the exaggerated pressor response to norepinephrine in rabbits with renal artery stenosis?

Population

Rabbits with renal artery stenosis (1-kidney, 1 clip Goldblatt) of 3-days' duration and sham operated rabbits

Intervention

Infusion of two angiotensin II antagonists ([1-Sar, 8-Ileu] angiotensin II and [1-Sar, 8-Ara] angiotensin II)

Comparator

Sham operated rabbits

Outcome

Pressor response to norepinephrine (NE) infusionsurrogate

Angiotensin II plays a critical role in the exaggerated pressor response to norepinephrine in prehypertensive rabbits with renal artery stenosis.

Discussion

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Implication

Supports angiotensin II mediation of norepinephrine hyperresponse in early renovascular models; hypothesis-generating for human renal artery stenosis.

Cite This Study

Kogure et al. (1984) studied this question.

synapsesocial.com/papers/6a854c446e0f1d231d201a4d https://doi.org/10.2974/kmj1951.34.465

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Implication

Supports angiotensin II mediation of norepinephrine hyperresponse in early renovascular models; hypothesis-generating for human renal artery stenosis.

Comparative Effect of Two Different Angiotessin Ii

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Comparative Effect of Two Different Angiotessin Ii

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider