Why the study?
Does vasopressin infusion cause an exaggerated pressor response in rabbits with 3-day renal artery stenosis compared to controls, and is this mediated by angiotensin II?
Population
Conscious one-kidney rabbits with 3-day renal artery stenosis
Comparison
Intravenous infusion of arginine vasopressin at… vs One-kidney rabbits without renal artery stenosis
Design
Preclinical
Follow-up
Acute (5 minute infusion)
Authors
Loading...
Supports angiotensin II mediation of vasopressin hyperresponsiveness in experimental renal artery stenosis; leaves open translation to human renovascular hypertension.
Does vasopressin infusion cause an exaggerated pressor response in rabbits with 3-day renal artery stenosis compared to controls, and is this mediated by angiotensin II?
In a rabbit model of 3-day renal artery stenosis, exaggerated pressor responses to vasopressin are mediated by angiotensin II, indicating the hyperresponsiveness is not specific to a single pressor agent.
Johnson et al. (1981) studied this question.