Population
20 albino rabbits undergoing unilateral nephrectomy and renal artery stenosis (clip I.D. = 0.508 mm)
Comparison
Electrolytic lesions along the anteroventral… vs Sham lesions
Design
Preclinical
Follow-up
4 weeks after renal artery stenosis
Authors
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AV3V lesions blunt renal hypertension in rabbits; hypothesis-generating for central mechanisms, no clinical implications yet.
Forebrain AV3V lesions attenuate the rise in blood pressure in a rabbit model of one-kidney renal hypertension, indicating central neurohormonal involvement.
Fink et al. (1983) studied this question.
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