Why the study?
Does ablation of AV3V tissue prevent hypertension in a rat model of two-kidney, one-clip renal hypertension?
Population
Rats (two-kidney, one-clip model of renal hypertension)
Comparison
Ablation of anteroventral third ventricle tissue vs Sham lesion
Design
Preclinical
Authors
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Supports central AV3V involvement in rat renovascular hypertension; hypothesis-generating with no implications for human therapy.
Does ablation of AV3V tissue prevent hypertension in a rat model of two-kidney, one-clip renal hypertension?
Ablation of the AV3V tissue prevents the development of sustained hypertension in the two-kidney, one-clip rat model.
Haywood et al. (1983) studied this question.
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