Population
Rats with two-kidney, one-clip (2K1C) and one-kidney, one-clip (1K1C) Goldblatt hypertension models
Comparison
Renal artery stenosis vs Sham controls
Design
Preclinical
Follow-up
28 days
Authors
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Body fluid changes may contribute to hypertension in 1K1C but not 2K1C rats; leaves open translational relevance to human renovascular hypertension.
Alterations in body fluid volumes may be involved in the development and maintenance of hypertension in 1K1C rats, but not in 2K1C rats, while the renin-angiotensin system plays a negligible role in both models.
Yagi et al. (1987) studied this question.
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