Why the study?
Do different hemodynamic patterns in 1K1C and 2K1C renovascular hypertension models lead to different types of left ventricular adaptation in rats?
Population
102 Wistar rats (28 two-kidney, one clip [2K1C], 19 one-kidney, one clip [1K1C], and 55 age-matched controls)
Comparison
One-kidney, one clip and two-kidney, one clip… vs Age-matched control animals
Design
Preclinical
Follow-up
8 weeks after surgery
Authors
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Distinguishes volume- vs pressure-overload LV effects in rat hypertension models; leaves open translation to human renovascular disease.
Do different hemodynamic patterns in 1K1C and 2K1C renovascular hypertension models lead to different types of left ventricular adaptation in rats?
Different models of renovascular hypertension in rats produce distinct patterns of left ventricular hypertrophy, with volume-dependent hypertension causing greater mass increase and chamber enlargement.
Simone et al. (1992) studied this question.
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