Key result
In rats with Goldblatt hypertension, LV fractional shortening was inversely related to end-systolic stress (r = -0.89 to -0.95, P<0.00001), with increased contractility maintaining function when hypertrophy was inadequate.
Effect estimate: r = -0.89 to -0.95
p-value: p=<.00001
In a rat model of Goldblatt hypertension, normal LV function is maintained either by adequate LV hypertrophy normalizing afterload or by increased contractility when hypertrophy is inadequate.
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Should not alter clinical management in hypertension; extends preclinical insights on LV compensation but requires human validation.
Simone et al. (1992) studied Goldblatt hypertension (n=79). One-kidney, one-clip (1K1C) and two-kidney, one-clip (2K1C) clipping vs. Sham-operated and normal rats was evaluated on Relationship between left ventricular fractional shortening and end-systolic stress (r = -0.89 to -0.95, p=<.00001). In rats with Goldblatt hypertension, LV fractional shortening was inversely related to end-systolic stress (r = -0.89 to -0.95, P<0.00001), with increased contractility maintaining function when hypertrophy was inadequate.
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