Why the study?
Does two-kidney, one clip Goldblatt hypertension alter total venous capacity over time in conscious rats?
Population
Conscious rats with early, intermediate and chronic phases of two-kidney, one clip Goldblatt hypertension
Comparison
Two-kidney, one clip Goldblatt hypertension model vs Sham-operated control rats
Design
Preclinical
Authors
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Animal data link chronic hypertension to decreased venous capacity; leaves open translation to human hemodynamics or therapy.
Does two-kidney, one clip Goldblatt hypertension alter total venous capacity over time in conscious rats?
Decreased venous capacity in chronic hypertensive rats appears to be a secondary hemodynamic state not related to decreased venous compliance.
Yamamoto et al. (1982) studied this question.
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