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February 1, 1986Acta Physiologica Scandinavica

Functional, morphological and metabolic characteristics of isolated hearts from normotensive and spontaneously hypertensive rats before, during and after renal hypertension

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Why the study?

Does superimposed renal hypertension alter cardiac performance in spontaneously hypertensive and normotensive rats?

Population

Spontaneously hypertensive rats (SHR) and normotensive control rats (NCR)

Comparison

Superimposed two-kidney, one clip Goldblatt… vs Normotensive control rats and SHR before renal…

Design

Preclinical

Follow-up

1 week after reversal of hypertension

Authors

PFPeter FribergPreventive CardiologyCNClaes NordborgSahlgrenska University Hospital

Discussion

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Implication

Renal hypertension may depress performance in hypertrophied hearts independent of fibrosis; animal data leave open relevance to human hypertension.

Structured PICO

Does superimposed renal hypertension alter cardiac performance in spontaneously hypertensive and normotensive rats?

P
Population
Spontaneously hypertensive rats (SHR) and normotensive control rats (NCR)
I
Intervention
Superimposed two-kidney, one clip Goldblatt hypertension (renal hypertension) and its reversal by unclipping
C
Comparator
Normotensive control rats (NCR) and SHR before renal hypertension
O
Outcome
Left ventricular function (cardiac performance) determined in an antegrade working heart perfusion systemsurrogate

Left ventricular hypertrophy generally enhances cardiac performance, but concomitant renal hypertension exerts a cardio-depressive influence independent of fibrous tissue content or energy charge potential.

Cite This Study

Friberg et al. (1986) studied this question.

synapsesocial.com/papers/6a7e27f1fdb0e04bb5e9711ehttps://doi.org/10.1111/j.1748-1716.1986.tb07802.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Cardiac performance in rats with renal hypertension.1976 · 77 citations
  2. 2Left ventricular hypertrophy in rats with renovascular hypertension. Alterations in cardiac function and adrenergic responses.1981 · 58 citations
  3. 3Left ventricular hypertrophy improves cardiac performance in spontaneously hypertensive rats1982 · 20 citations
  4. 4Performance of the hypertrophied left ventricle in spontaneously hypertensive rat. Effects of changes in preload and afterload1979 · 34 citations
  5. 5Rate and Extent of Adaptive Cardiovascular Changes in Rats during Experimental Renal Hypertension1974 · 91 citations