What does this research mean for the field?

Spontaneously hypertensive rat colonies develop different geometric forms of left ventricular hypertrophy, with eccentric hypertrophy conferring superior cardiac performance compared to concentric hypertrophy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 2, 1990European Heart Journal

Cardiac and vascular structural adaptation in experimental hypertension

Q: What is the clinical evidence from this study?

Study design: Other. Population: Experimental hypertension. Intervention: Experimental hypertension (SHR and renal hypertension). Primary outcome: Left ventricular structural adaptation and cardiac function.

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Key result

Eccentric LVH shows enhanced cardiac function compared to concentric LVH in spontaneously hypertensive rats.

Why the study?

Different colonies of spontaneously hypertensive rats exhibit varying left ventricular structural adaptations and function, with unclear relations to blood pressure and cardiac filling patterns.

Population

Spontaneously hypertensive rats from Australian, Swiss, and Danish colonies and renal hypertensive rats

Comparison

Concentric versus eccentric left ventricular hypertrophy and renal hypertension effects

Design

Experimental study in animal models

Authors

PFPeter FribergPreventive Cardiology MAMichael A. AdamsLawrence Berkeley National Laboratory

Discussion

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Implication

SHR colony variability cautions against assuming uniform LV remodeling in preclinical hypertension models; leaves open genetic and environmental determinants of concentric vs eccentric hypertrophy.

PICO

Population

Experimental hypertension

Exposure / Comparator

Experimental hypertension (SHR and renal hypertension)

Primary Outcome

Left ventricular structural adaptation and cardiac function

Cite This Study

Friberg et al. (1990) studied Experimental hypertension. Experimental hypertension (SHR and renal hypertension) was evaluated on Left ventricular structural adaptation and cardiac function. Spontaneously hypertensive rats exhibit varying forms of left ventricular hypertrophy depending on their colony, with eccentric hypertrophy demonstrating enhanced cardiac function compared to concentric.

synapsesocial.com/papers/6ab863bae3a4fe9e336fa53b https://doi.org/10.1093/eurheartj/11.suppl_g.65

Topics

Hypertension management

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Implication

SHR colony variability cautions against assuming uniform LV remodeling in preclinical hypertension models; leaves open genetic and environmental determinants of concentric vs eccentric hypertrophy.

Cardiac and vascular structural adaptation in experimental hypertension

Discussion

Member takes

Implication

PICO

Cite This Study

Topics

Cardiac and vascular structural adaptation in experimental hypertension

Discussion

Member takes

Implication

PICO

Cite This Study

Also Consider

Topics

Also Consider