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January 1, 1984HypertensionOpen Access

Effects of graded renal artery constriction on blood pressure, renal artery pressure, and plasma renin activity in Goldblatt hypertension.

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Why the study?

Does graded renal artery constriction affect blood pressure and plasma renin activity differently in 1K1C versus 2K1C Goldblatt hypertension models in rats?

Population

Rats with One-kidney, one clip (1K1C) and two-kidney, one clip (2K1C) Goldblatt hypertension

Comparison

Graded renal artery constriction using 0.30… vs Control rats without clips

Design

Preclinical

Follow-up

24 to 28 days

Authors

WMWilliam R. MurphyWichita State UniversityTCT. G. ColemanUniversity of MississippiTSThomas L. SmithWake Forest University

Discussion

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Implication

Does not support practice changes in renovascular hypertension; leaves open translation of 1K1C versus 2K1C model differences to humans.

Structured PICO

Does graded renal artery constriction affect blood pressure and plasma renin activity differently in 1K1C versus 2K1C Goldblatt hypertension models in rats?

P
Population
Rats with One-kidney, one clip (1K1C) and two-kidney, one clip (2K1C) Goldblatt hypertension
I
Intervention
Graded renal artery constriction using 0.30, 0.25, or 0.20 mm silver clips on the left renal artery
C
Comparator
Control rats without clips
O
Outcome
Mean arterial pressure (MAP) and plasma renin activity (PRA) at 24 to 28 dayssurrogate

In rat models of Goldblatt hypertension, one-kidney one-clip models exhibit greater increases in mean arterial pressure and trans-clip pressure gradients compared to two-kidney one-clip models for any given degree of renal artery constriction.

Cite This Study

Murphy et al. (1984) studied this question.

synapsesocial.com/papers/6a7160eb439bab0cabc38e34https://doi.org/10.1161/01.hyp.6.1.68

Topics

Hypertension management
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma renin concentration in hypertension produced by unilateral renal artery constriction in the rat1975 · 19 citations
  2. 2Intrarenal renin-angiotensin-sodium interdependent mechanism controlling postclamp renal artery pressure and renin release in the conscious dog with chronic one-kidney Goldblatt hypertension.1977 · 22 citations
  3. 3Bilateral renal function responses to converting enzyme inhibitor (SQ 20,881) in two-kidney, one clip Goldblatt hypertensive rats.1981 · 91 citations
  4. 4Measurement of Renal Artery Pressure in the Rat1982 · 2 citations