Population
72 untreated male Sprague-Dawley rats with two-kidney, one clip (2K1C) renal hypertension model
Design
Preclinical
Follow-up
6 to 8 weeks after clipping
Authors
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Supports refined 2K1C model selection; extends preclinical utility while leaving human translation open.
An LK/RK ratio of 0.5 to 0.8 reliably identifies rats that develop hypertension in the 2K1C model, providing an objective selection criterion for drug-treated animals.
Smith et al. (1986) studied this question.
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