Why the study?
Does the 1K1C Goldblatt hypertension model increase right ventricular systolic pressure compared to the 2K1C model and controls in rats?
Population
Male Sprague-Dawley rats
Comparison
One-kidney, one clip Goldblatt hypertension… vs Control group and two kidneys, one clip…
Design
Preclinical
Follow-up
28 days
Authors
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The 1K1C Goldblatt hypertension model, but not the 2K1C model, significantly increases right ventricular systolic pressure in rats, a response that may be partially mediated by reactive oxygen species.
Does the 1K1C Goldblatt hypertension model increase right ventricular systolic pressure compared to the 2K1C model and controls in rats?
The 1K1C Goldblatt hypertension model, but not the 2K1C model, significantly increases right ventricular systolic pressure in rats, a response that may be partially mediated by reactive oxygen species.
Ketabchi et al. (2017) studied this question.
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