Why the study?
Does high-salt intake alter the course of the development and magnitude of hypertension or influence renal function in two-kidney, one clip Goldblatt hypertensive rats?
Population
Two-kidney, one clip (2K1C) Goldblatt hypertensive rats
Comparison
0.9% sodium chloride as a drinking solution for… vs Water-drinking clipped rats and control animals
Design
Preclinical
Follow-up
3 weeks
Authors
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High-salt effects in this 2K1C model should not change clinical practice; leaves open translation to human renovascular hypertension.
Does high-salt intake alter the course of the development and magnitude of hypertension or influence renal function in two-kidney, one clip Goldblatt hypertensive rats?
In a 2K1C renovascular hypertension rat model, high-salt intake suppresses the renin-angiotensin system and delays the onset of hypertension without affecting its final magnitude, while improving function in the clipped kidney.
Jackson et al. (1986) studied this question.
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