Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 1983HypertensionOpen Access

Pressor responses to norepinephrine during captopril in renal prehypertensive rabbits.

View Full Paper
Ask AI
Bookmark
Share

Population

Conscious one-kidney, one clip rabbits with renal artery stenosis of 3-days' duration and conscious…

Comparison

Captopril with intravenous infusions of… vs Norepinephrine alone, and control rabbits…

Design

Preclinical

Authors

DKD. G. KoivunenHarry S. Truman Memorial Veterans' HospitalJJJ. A. JohnsonAnglia Ruskin UniversityWNW K NicholsUniversity of Utah

Discussion

Loading...

Member takes

Overview

Supports angiotensin II role in norepinephrine hypersensitivity in renal artery stenosis models; leaves open translation to human renovascular hypertension.

Structured PICO

P
Population
Conscious one-kidney, one clip rabbits with renal artery stenosis of 3-days' duration (renal prehypertensive rabbits) and conscious one-kidney control rabbits without renal artery stenosis (n=36).
I
Intervention
Captopril (SQ 14,225) with intravenous infusions of norepinephrine (25 to 1200 ng/min/kg) and/or angiotensin II (0.5, 1.0, and 2.0 ng/min/kg).
C
Comparator
Norepinephrine alone, and control rabbits without renal artery stenosis.
O
Outcome
Pressor responses to intravenous infusions of norepinephrine.surrogate

Angiotensin II plays an important role in the enhanced pressor responses to norepinephrine in early renal artery stenosis, independent of elevated plasma levels of angiotensin II.

Cite This Study

Koivunen et al. (1983) studied this question.

synapsesocial.com/papers/6a8299dbc00c8d0185b27fb6https://doi.org/10.1161/01.hyp.5.2.159
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of Angiotensin Infusion on Catecholamine Uptake and Reactivity in Blood Vessels1971 · 54 citations
  2. 2Effect of angiotensin on the response to noradrenaline and sympathetic nerve stimulation, and on 3H-noradrenaline uptake in cat mesenteric blood vessels1968 · 54 citations
  3. 3Vascular Resistance and Reactivity in Hypertensive Rats2008 · 63 citations
  4. 4Measurement of Plasma Angiotensin II and Correlation with Renin Activity1968 · 32 citations
  5. 5Interaction of Angiotensin and Noradrenaline in Rat's Hindlimb Preparation. : A Possible Mechanism of the Experimental Renal Hypertension1971 · 10 citations