Key result
In conscious rabbits, captopril markedly reduced the pressor and heart rate responses to bilateral carotid occlusion, which were fully restored by angiotensin II replacement (p<0.05).
Why the study?
Does endogenous angiotensin II facilitate cardiovascular responses to sympathetic stimulation in conscious rabbits?
Does endogenous angiotensin II facilitate cardiovascular responses to sympathetic stimulation in conscious rabbits?
p-value: p=<0.05
Endogenous angiotensin II plays an important role in facilitating cardiovascular responses to sympathetic stimulation, likely through a presynaptic mechanism rather than altering baroreflex sensitivity.
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Supports presynaptic facilitation by angiotensin II in rabbit sympathetic responses; leaves open translation to human baroreflex or ACE inhibitor effects.
Isaacson et al. (1990) studied this question. Captopril and Angiotensin II replacement vs. Control period (baseline) was evaluated on Pressor and heart rate responses to bilateral carotid occlusion (p=<0.05). In conscious rabbits, captopril markedly reduced the pressor and heart rate responses to bilateral carotid occlusion, which were fully restored by angiotensin II replacement (p<0.05).
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