What does this research mean for the field?

Exogenous angiotensin-I significantly enlarges myocardial ischaemia by 35%, an effect that is completely prevented by captopril. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 1993European Heart Journal

Deleterious effect of exogenous angiotensin-I on the extent of regional ischaemia and its inhibition by captopril

Q: What are the key findings of this study?

Exogenous angiotensin-I significantly enlarged myocardial ischaemia by 35% (P<0.05), an effect that was completely prevented by the addition of captopril.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Myocardial ischaemia. Intervention: Exogenous angiotensin-I and captopril vs. Absence of exogenous angiotensin-I / captopril alone. Primary outcome: Extent of regional myocardial ischaemia (p=<0.05).

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Key result

Exogenous angiotensin-I enlarges myocardial ischemia by ~35%, an effect completely prevented by captopril.

P<0.05

Why the study?

The endogenous activity of the local renin-angiotensin system and the anti-ischaemic properties of captopril in isolated rabbit hearts were unclear.

Does captopril inhibit the deleterious effect of exogenous angiotensin-I on regional ischemia in isolated rabbit hearts?

Population

Electrically driven rabbit Langendorff hearts with induced myocardial ischaemia

Comparison

Exogenous angiotensin-I with or without captopril versus absence of exogenous angiotensin-I or captopril alone

Design

Preclinical experimental study

Authors

ARA.F.E. RumpUniversität der Bundeswehr München TRT. J. ROSENUniversity of Cologne AKAnnette KorthUniversity of Cologne

Discussion

Member takes

Implication

Captopril blocks angiotensin-I worsening of ischemia in rabbit hearts; leaves open direct cardioprotection and human translation.

Structured PICO

Does captopril inhibit the deleterious effect of exogenous angiotensin-I on regional ischemia in isolated rabbit hearts?

Population

Isolated electrically driven rabbit Langendorff hearts subjected to experimental myocardial ischaemia.

Intervention

Exogenous angiotensin-I (6 x 10(-9) mol.l-1) with or without captopril (10(-6) mol.l-1)

Comparator

Absence of exogenous angiotensin-I or captopril alone

Outcome

Extent of myocardial ischemia (quantified from NADH surface fluorescence photography) and global coronary flowsurrogate

Main Result

p-value: p=<0.05

In isolated rabbit hearts, captopril prevents the exacerbation of myocardial ischemia induced by exogenous angiotensin-I but lacks direct cardioprotective properties independent of ACE inhibition.

Cite This Study

Rump et al. (1993) studied Myocardial ischaemia. Exogenous angiotensin-I and captopril vs. Absence of exogenous angiotensin-I / captopril alone was evaluated on Extent of regional myocardial ischaemia (p=<0.05). Exogenous angiotensin-I significantly enlarged myocardial ischaemia by 35% (P<0.05), an effect that was completely prevented by the addition of captopril.

synapsesocial.com/papers/6ab0898eedee64972803bc25 https://doi.org/10.1093/eurheartj/14.1.106

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Deleterious effect of exogenous angiotensin-I on the extent of regional ischaemia and its inhibition by captopril

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

Deleterious effect of exogenous angiotensin-I on the extent of regional ischaemia and its inhibition by captopril

Discussion

Member takes

Implication

Structured PICO

Main Result

Cite This Study

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