Population
Isolated rat hindquarters perfused with an artificial medium
Comparison
Angiotensinase inhibitors and renin infusion vs Controls and exogenous angiotensin II infusion
Design
Preclinical
Authors
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Supports local angiotensin degradation in tissues; leaves open human translation and clinical relevance.
Locally generated angiotensins are primarily degraded by tissue angiotensinases rather than released into the systemic circulation.
Hilgers et al. (1998) studied this question.
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