What does this research mean for the field?

The heart is capable of local Angiotensin II production, resulting in higher tissue levels than in blood plasma, with evidence suggesting potential intracellular production alongside AT1-receptor-mediated cellular uptake. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1998HypertensionOpen Access

Localization and Production of Angiotensin II in the Isolated Perfused Rat Heart

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Population

Isolated perfused rat hearts (n=26 across various perfusion experiments)

Comparison

Perfusion with combined renin and… vs Coronary effluent vs interstitial transudate…

Design

Preclinical

Follow-up

60 minutes

Authors

LLLarissa M. de LannoyLeiden University ADA.H. Jan DanserVascular Medicine ABAngelique M. BouhuizenErasmus MC

Discussion

Member takes

Implication

Caution against extrapolating rat heart Ang II gradients to patients; extends tissue RAS understanding but remains hypothesis-generating.

Structured PICO

Population

Isolated perfused rat hearts (n=26 across various perfusion experiments)

Intervention

Perfusion with combined renin (0.7 to 1.5 pmol Ang I/mL per minute) and angiotensinogen (6 to 12 pmol/mL), Angiotensin I, or Angiotensin II, with or without the addition of losartan (10^-6 mol/L)

Comparator

Coronary effluent vs interstitial transudate; presence vs absence of losartan

Outcome

Steady-state levels and tissue concentration of Angiotensin IIsurrogate

The isolated rat heart can locally produce Angiotensin II, resulting in higher tissue concentrations than plasma levels, partially mediated by AT1-receptor cellular uptake.

Cite This Study

Lannoy et al. (1998) studied this question.

synapsesocial.com/papers/6a1eb53e94615786b59a73bc https://doi.org/10.1161/01.hyp.31.5.1111

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Localization and Production of Angiotensin II in the Isolated Perfused Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Localization and Production of Angiotensin II in the Isolated Perfused Rat Heart

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider