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September 1, 1990Circulation ResearchOpen Access

Cardiac angiotensinogen and its local activation in the isolated perfused beating heart.

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Population

Isolated, perfused rat hearts

Comparison

Infusions of purified hog renin vs Control conditions (absence of renin)

Design

Preclinical

Authors

KLKlaus LindpaintnerMJMingwei JinNNN. Niedermaier

Discussion

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Overview

Supports cardiac RAS in isolated hearts; leaves open its role in human disease.

Structured PICO

P
Population
Isolated, perfused rat hearts
I
Intervention
Infusions of purified hog renin (concentrations between 10 microunits/ml and 5 milliunits/ml)
C
Comparator
Control conditions (absence of renin)
O
Outcome
Generation of Angiotensin I (Ang I) and Angiotensin II (Ang II) in coronary sinus effluentsurrogate

The study demonstrates that biologically active angiotensin peptides can be formed within the isolated heart from locally present substrate, supporting the existence of a functional cardiac renin-angiotensin system.

Cite This Study

Lindpaintner et al. (1990) studied this question.

synapsesocial.com/papers/6a10693b28c2d29469fe74fdhttps://doi.org/10.1161/01.res.67.3.564
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