What question did this study set out to answer?

The aim is to determine how rabbit antibodies against angiotensin-II affect blood pressure responses in rats.

November 1, 1968British Journal of PharmacologyOpen Access

Effect of rabbit antibodies against angiotensin‐II on the pressor response to angiotensin‐II and renal hypertension in the rat

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Why the study?

Does anti-angiotensin serum reduce the pressor response to angiotensin-II and blood pressure in rats?

Population

Intact, nephrectomized, or renal hypertensive rats

Design

Preclinical

Follow-up

2.5 hours

Authors

PHP. R. HedwallOregon Health & Science University

Discussion

Member takes

Implication

Acute angiotensin-II neutralization fails to lower BP in renal hypertensive rats; leaves open its role in sustaining hypertension.

Key Points

The aim is to determine how rabbit antibodies against angiotensin-II affect blood pressure responses in rats.
Measuring pressor responses to angiotensin-II-amide and other related substances in intact and nephrectomized rats.
Administering intravenous injections of rabbit serum containing antibodies and assessing effects on blood pressure.
Evaluating responses to vasopressin and noradrenaline in connection with anti-angiotensin serum treatment.
Inhibition of pressor responses to synthetic angiotensin-II-amide for 2.5 hours after anti-angiotensin serum injection.
No effect of anti-angiotensin serum on pressor responses to vasopressin or noradrenaline.
Intravenous infusion or daily injection of anti-angiotensin serum did not alter blood pressure in renal hypertensive rats.

Structured PICO

Does anti-angiotensin serum reduce the pressor response to angiotensin-II and blood pressure in rats?

Population

Intact, nephrectomized, or renal hypertensive rats

Intervention

Rabbit serum containing antibodies against synthetic angiotensin-II-amide (anti-angiotensin serum) administered via intravenous injection, intravenous infusion, or daily intraperitoneal injection

Outcome

Pressor response to angiotensin-II and blood pressure levelssurrogate

Rabbit antibodies against angiotensin-II inhibit the acute pressor response to angiotensin-II but do not lower blood pressure in renal hypertensive rats.

Cite This Study

P. R. Hedwall (1968) studied this question.

synapsesocial.com/papers/6a7cc327273accedbda8b39d https://doi.org/10.1111/j.1476-5381.1968.tb08491.x

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Effect of rabbit antibodies against angiotensin‐II on the pressor response to angiotensin‐II and renal hypertension in the rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Effect of rabbit antibodies against angiotensin‐II on the pressor response to angiotensin‐II and renal hypertension in the rat

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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