Key result
Immunization against angiotensin II produced adequate antibodies but did not significantly reduce blood pressure in spontaneously-hypertensive rats.
Why the study?
Does immunization with angiotensin II reduce blood pressure in spontaneously-hypertensive rats?
Does immunization with angiotensin II reduce blood pressure in spontaneously-hypertensive rats?
Immunization against angiotensin II does not reduce blood pressure in spontaneously-hypertensive rats, suggesting angiotensin II is not the primary etiological factor in this hypertension model.
Warrants caution against Ang II immunization for hypertension; leaves open its role beyond the SHR model.
To assess the role of angiotensin II in spontaneously-hypertensive rats, the blood pressure response and the presence of antibodies determined serially by radioimmunoassay techniques after immunization with angiotensin II were studied. Despite the development of adequate antibodies in each of eleven rats, no rat had a significant reduction in blood pressure. As compared with normal albino rats immunized similarly, the antibody levels of the spontaneously-hypertensive rats exceeded that of the normal rats. The results suggest first that angiotensin is not an etiological factor in the hypertension of spontaneously-hypertensive rats, and second that there is a quantitative individual and species variation among rats in their ability to form angiotensin II antibody. Recent results of the blood pressure response to renin and angiotensin II inhibition in various models of experimental hypertension are discussed. (Endocrinology91: 1064, 1972)
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Christlieb et al. (1972) studied Hypertension (n=11). Immunization against Angiotensin II vs. Normal albino rats immunized similarly was evaluated on Blood pressure response and antibody formation. Immunization against angiotensin II produced adequate antibodies but did not significantly reduce blood pressure in spontaneously-hypertensive rats.
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