Key result
Angiotensin II inhibition demonstrated that angiotensin II is critically involved in renal hypertension with an intact contralateral kidney, but not when the opposite kidney is removed.
Why the study?
Does angiotensin II inhibition affect blood pressure differently in two models of experimental renal hypertension in rats?
Does angiotensin II inhibition affect blood pressure differently in two models of experimental renal hypertension in rats?
This study provides early evidence that the renin-angiotensin system's role in renal hypertension depends on the presence of the contralateral kidney.
Differentiates angiotensin II dependence by renal hypertension model; leaves open translation to human renovascular disease.
Antibody to angiotensin 11, or a specific peptide competitive inhibitor of angiolensin II, was used to investigate the role of the renin-angiotensin system in two types of renal hypertension in rats. The data indicate that angiotensin II is in fact critically involved in the pathogenesis of the form of renal hypertension in which one renal artery is clamped and the contralateral kidney is left in place, but that it probably plays no significant role in the maintenance of experimental renal hypertension in which the opposite kidney has been removed.
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Brunner et al. (1971) studied Renal hypertension. Antibody to angiotensin II or specific peptide competitive inhibitor of angiotensin II was evaluated on Role of angiotensin II in pathogenesis and maintenance of renal hypertension. Angiotensin II inhibition demonstrated that angiotensin II is critically involved in renal hypertension with an intact contralateral kidney, but not when the opposite kidney is removed.
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