Key result
Antirenin antibodies and RAS inhibitors lower blood pressure in hypertensive rats but require intact kidneys.
Why the study?
Do inhibitors of the renin-angiotensin system lower blood pressure in spontaneously hypertensive rats, and what is the source of vascular renin?
Do inhibitors of the renin-angiotensin system lower blood pressure in spontaneously hypertensive rats, and what is the source of vascular renin?
This preclinical study demonstrates that membrane-associated renin of renal origin plays a critical role in the maintenance of hypertension in spontaneously hypertensive rats.
Renin-angiotensin blockade may require intact kidneys in this model; leaves open extrarenal renin contributions to hypertension.
Inhibitors of angiotensin-converting enzyme, renin and angiotensin II receptor lower the blood pressure of spontaneously hypertensive rats (SHRs) used as a model of essential hypertension. Since their plasma renin levels were normal or subnormal, renin in the vascular tissue was considered to play a key role in the maintenance of the hypertension. To clarify the source and localization of vascular renin in SHRs, the effects on blood pressure of antirenin antibodies, the converting enzyme inhibitors delapril and enalapril, and the angiotensin II receptor antagonist DuP 753 were examined in intact and bilaterally nephrectomized SHRs and their normotensive controls. The efficient hypotensive action of the renin antibody indicated that renin of the renal origin is a dominant factor. The gradual but complete disappearance of the antihypertensive action of these inhibitors of the renin-angiotensin system upon bilateral nephrectomy indicated the importance of membrane-associated renin of the renal origin and angiotensin-converting enzyme in the maintenance of the spontaneous hypertension.
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Inagami et al. (2008) studied essential hypertension (animal model). Antirenin antibodies, delapril, enalapril, and DuP 753 vs. Normotensive controls and intact vs bilaterally nephrectomized status was evaluated on Blood pressure. Antirenin antibodies and renin-angiotensin system inhibitors lowered blood pressure in intact spontaneously hypertensive rats, but this effect disappeared upon bilateral nephrectomy.
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