Key result
Cerebroventricular administration of Ang-(1-7) antibody in transgenic hypertensive rats caused significant dose-related elevations in blood pressure and tachycardia, opposing the effects of Ang II.
Why the study?
Does cerebroventricular administration of Ang-(1-7) antibody or Ang II antibody alter blood pressure and heart rate in transgenic hypertensive rats?
Population
12-week-old conscious homozygous female rats expressing the mouse submandibular Ren-2d gene [27] and…
Comparison
Cerebroventricular administration of… vs Central injections of an affinity-purified IgG…
Design
Preclinical
Authors
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Central Ang-(1-7) opposes Ang II effects on BP in hypertensive rats; leaves open translation to human therapy.
Does cerebroventricular administration of Ang-(1-7) antibody or Ang II antibody alter blood pressure and heart rate in transgenic hypertensive rats?
In the brain of transgenic hypertensive rats, Ang-(1-7) opposes the action of Ang II on central mechanisms contributing to hypertension maintenance.
Moriguchi et al. (1995) studied Hypertension. Cerebroventricular administration of Ang-(1-7) antibody or Ang II monoclonal antibody vs. Affinity-purified IgG fraction was evaluated on Blood pressure and heart rate. Cerebroventricular administration of Ang-(1-7) antibody in transgenic hypertensive rats caused significant dose-related elevations in blood pressure and tachycardia, opposing the effects of Ang II.
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