Why the study?
Does immunization with angiotensin II prevent the development of renal hypertension in a rabbit model?
Population
12 rabbits with induced renal hypertension
Comparison
Immunization with angiotensin II vs No immunization (control rabbits)
Design
Preclinical
Follow-up
4 weeks plus a few days
Authors
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Questions role of acute angiotensin effects in renal hypertension; hypothesis-generating for human mechanisms.
Does immunization with angiotensin II prevent the development of renal hypertension in a rabbit model?
Renal hypertension induced in rabbits is not dependent on the acute pressor effect of angiotensin and renin, as immunized rabbits still developed hypertension despite neutralizing antibodies.
Eide et al. (1970) studied this question.
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