Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1970Circulation ResearchOpen Access

Renal-Clip Hypertension in Rabbits Immunized Against Angiotensin II

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does immunization against angiotensin II prevent or modify renal-clip hypertension in rabbits?

Population

Rabbits immunized against angiotensin II (n=8 mentioned)

Design

Preclinical

Authors

GMGraham MacdonaldNHS GrampianWLWilliam J. LouisNorthern HealthVRV. RenziniUniversity of Perugia

Discussion

Loading...

Member takes

Implication

Ang II immunization neither prevents nor reverses renal-clip hypertension in rabbits despite blockade; challenges its primacy and leaves open multifactorial mechanisms in renovascular models.

Key Points

  • To determine whether circulating angiotensin II is required for the initiation or maintenance of renal-clip hypertension.
  • Immunized rabbits against angiotensin II to validate specific and complete in vivo blockade of the pressor response to high-dose intravenous renin and angiotensin.
  • Evaluated hypertension onset following renal-artery clipping with contralateral nephrectomy in 4 immunized rabbits, and tested immunization effects on established hypertension in 4 rabbits.
  • Renal-artery clipping produced hypertension in all 4 immunized rabbits, with severe hypertension developing in 3 animals despite proven blockade of pressor responses.
  • Immunization against angiotensin II produced no observable reduction or modification of established hypertension in 4 rabbits, demonstrating angiotensin II is not the primary driver of this pathology.

Structured PICO

Does immunization against angiotensin II prevent or modify renal-clip hypertension in rabbits?

P
Population
Rabbits immunized against angiotensin II (n=8 mentioned)
I
Intervention
Renal-artery clipping with contralateral nephrectomy (to induce hypertension) or immunization after established hypertension
O
Outcome
Development or modification of hypertensionsurrogate

The study demonstrates that angiotensin II is not the sole or major factor in the initiation or maintenance of renal-clip hypertension in rabbits.

Cite This Study

Macdonald et al. (1970) studied this question.

synapsesocial.com/papers/6a7cc327273accedbda8b397https://doi.org/10.1161/01.res.27.2.197
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Renin in Experimental Renal Hypertension in Monkeys1963 · 34 citations
  2. 2GENERATION AND USE OF ANTIBODIES TO ANGIOTENSIN II1967 · 21 citations
  3. 3THE METABOLIC CLEARANCE RATE OF ALDOSTERONE IN PREGNANT AND NONPREGNANT SUBJECTS ESTIMATED BY BOTH SINGLE-INJECTION AND CONSTANT-INFUSION METHODS*1962 · 157 citations
  4. 4The radioimmunoassay of angiotensin II1969 · 35 citations
  5. 5Renin and Angiotensin Tachyphylaxis1961 · 58 citations