Acute renal haemodynamic and renin‐angiotensin system responses to graded renal artery stenosis in the dog.
Population
Chronically instrumented, unanaesthetized dogs
Comparison
Graded renal artery stenosis induced by cuff… vs Pre-stenosis values and comparison between…
Design
Preclinical
Follow-up
1 hour
Authors
Discussion
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Implication
Suggests RAS dependence in acute experimental stenosis recovery; leaves open human relevance and clinical translation.
Structured PICO
P
Population
Chronically instrumented, unanaesthetized dogs
I
Intervention
Graded renal artery stenosis induced by cuff inflation to lower distal pressure to 60, 40 or 20 mmHg for 1 hour, with or without pre-treatment with ACE inhibitor or saralasin (sarosine1, isoleucone8 angiotensin II)
C
Comparator
Pre-stenosis values and comparison between pre-treatment vs no pre-treatment
O
Outcome
Acute renal haemodynamic changes (renal vascular resistance, renal artery pressure, renal blood flow) and renin-angiotensin system responses (plasma renin and angiotensin levels)surrogate
The renin-angiotensin system is essential for the acute restoration of renal artery pressure and vascular resistance following renal artery stenosis.
Cite This Study
Anderson et al. (1979) studied this question.