The importance of renal vascular tone in determining the severity of renal artery stenosis in dogs.
Why the study?
Does the state of renal vascular tone during induction of renal artery stenosis affect subsequent systemic blood pressure and renin responses in dogs?
Population
Chronically instrumented dogs
Comparison
Alteration of renal vascular tone via brief… vs Saline infusion or conscious state
Design
Preclinical
Follow-up
Up to 24 hours
Authors
Discussion
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Implication
Renal vascular tone at stenosis onset may modulate BP responses in canine models; leaves open translation to human renovascular hypertension.
Key Points
- To determine how baseline renal vascular tone during the induction of renal artery stenosis affects subsequent systemic arterial blood pressure and plasma renin activity.
- Chronically instrumented, conscious dogs received brief renal artery infusions of acetylcholine, saline, methoxamine, or angiotensin II while narrowing the renal artery to reduce distal pressure to 40 mmHg.
- A second cohort underwent induction of a fixed aortic-renal artery pressure gradient while conscious and during pentobarbitone anesthesia.
- At one hour post-stenosis, systemic blood pressure rose by 4.3 ± 3.3, 11.3 ± 3.3, 28.9 ± 3.3, and 26.3 ± 2.8 mmHg, and plasma renin activity increased by 0.3 ± 0.24, 1.18 ± 0.42, 5.09 ± 1.38, and 4.02 ± 0.74 ng/ml/hr in acetylcholine-, saline-, methoxamine-, and angiotensin II-treated dogs, respectively.
- At 24 hours, stenosis induced under anesthesia increased systemic blood pressure by 15.7 ± 3.6 mmHg (P < 0.05) and plasma renin activity by 1.29 ± 0.42 ng/ml/hr (P < 0.05), compared to non-significant increases of 1.2 ± 3.6 mmHg and 0.25 ± 0.11 ng/ml/hr in conscious dogs.
Structured PICO
Does the state of renal vascular tone during induction of renal artery stenosis affect subsequent systemic blood pressure and renin responses in dogs?
P
Population
Chronically instrumented dogs
I
Intervention
Alteration of renal vascular tone via brief (2-3 min) renal artery infusions of acetylcholine, methoxamine, or angiotensin II, or via sodium pentobarbitone anaesthesia, during induction of renal artery stenosis
C
Comparator
Saline infusion or conscious state
O
Outcome
Systemic blood pressure and plasma renin activity (PRA)surrogate
The tone of the renal vascular bed at the time of stenosis induction is a major determinant of the severity of renal artery stenosis, significantly impacting subsequent blood pressure and renin responses.
Cite This Study
Anderson et al. (1980) studied this question.