February 1, 1986Hypertension
Renal and systemic effects of enalapril in chronic one-kidney hypertension.
Why the study?
Does continuous enalapril treatment alter blood pressure and renal function in conscious dogs with chronic one-kidney hypertension?
Population
13 conscious dogs with one-kidney renal artery stenosis
Comparison
Continuous enalapril (MK 421) treatment vs No enalapril treatment (untreated)
Design
Preclinical
Follow-up
2 weeks
Authors
Discussion
Loading...
Member takes
Implication
ACE inhibition may impair GFR without controlling BP in one-kidney hypertension; leaves open angiotensin II's primary role in renal preservation for human translation.
Structured PICO
Does continuous enalapril treatment alter blood pressure and renal function in conscious dogs with chronic one-kidney hypertension?
P
Population
13 conscious dogs with one-kidney renal artery stenosis
I
Intervention
Continuous enalapril (MK 421) treatment
C
Comparator
No enalapril treatment (untreated)
O
Outcome
Mean aortic pressure and renal function (glomerular filtration rate, renal blood flow, renal artery pressure)surrogate
In chronic one-kidney Goldblatt hypertension, angiotensin II primarily acts to preserve glomerular filtration rather than mediating the pressor response.
Cite This Study
Woods et al. (1986) studied this question.