Why the study?
Does developing and stable perinephritic hypertension alter left ventricular diastolic function in conscious dogs?
Does developing and stable perinephritic hypertension alter left ventricular diastolic function in conscious dogs?
In a canine model, early hypertension causes reversible, load-dependent changes in diastolic stiffness, whereas chronic stable hypertension leads to prolonged isovolumic relaxation without increased myocardial fibrosis.
No takes yet. Share an insight, caveat, or question.
Hypothesis-generating in canine model; leaves open relevance to human diastolic function in hypertension.
Gelpi et al. (1991) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: