Why the study?
Does continuous norepinephrine infusion alter the positive inotropic and chronotropic responses of isolated rat cardiac muscles?
Population
85 adult male rats
Comparison
Continuous norepinephrine infusion via… vs Sham-operated rats
Design
Preclinical
Follow-up
14 days
Authors
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May caution against prolonged norepinephrine in critical care; leaves open human cardiac translation.
Does continuous norepinephrine infusion alter the positive inotropic and chronotropic responses of isolated rat cardiac muscles?
Continuous norepinephrine infusion in rats induces selective left ventricular hypertrophy and alters inotropic and chronotropic responses, particularly affecting cyclicAMP-mediated pathways in the hypertrophied ventricle.
Brown et al. (1992) studied this question.
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