January 1, 1996Cardiovascular ResearchOpen Access

Different response of the rat left and right heart to norepinephrine

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Population

Female Sprague-Dawley rats

Comparison

Continuous intravenous infusion of… vs Control values

Design

Preclinical

Follow-up

Up to 72 hours

Authors

MIMichael IrlbeckLMU Klinikum OMO. MühlingRhön-Klinikum TIT. IwaiKyoto University

Discussion

Member takes

Implication

Norepinephrine induces LV-specific hypertrophy despite stronger RV hemodynamics in rats, fully blocked by carvedilol; leaves open differential remodeling mechanisms in human heart failure.

Structured PICO

Population

Female Sprague-Dawley rats

Intervention

Continuous intravenous infusion of norepinephrine (NE) at 200 µg/kg/h for 24, 48, and 72 h, or at 50, 100, and 200 µg/kg/h for 72 h, with or without carvedilol (0.5 mg/kg/h) coinfusion for 72 h

Comparator

Control values

Outcome

Hemodynamic effects (heart rate, cardiac output, total peripheral resistance, LV and RV dP/dtmax, RVSP, LVSP, end-diastolic pressures) and morphologic responses (weights of left and right ventricles)surrogate

Continuous norepinephrine infusion in rats produces more pronounced hemodynamic responses in the right ventricle but induces hypertrophy exclusively in the left ventricle, effects that are prevented by carvedilol.

Cite This Study

Irlbeck et al. (1996) studied this question.

synapsesocial.com/papers/6a7a69964c448619ca0e2557 https://doi.org/10.1016/s0008-6363(95)00188-3

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Implication

Norepinephrine induces LV-specific hypertrophy despite stronger RV hemodynamics in rats, fully blocked by carvedilol; leaves open differential remodeling mechanisms in human heart failure.

Different response of the rat left and right heart to norepinephrine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Different response of the rat left and right heart to norepinephrine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider