Why the study?
Does sympathetic nerve and alpha-adrenergic stimulation alter pulmonary vascular input impedance and hydraulic power in the cat lung during variations of cardiac output?
Population
Open chest cat preparation
Comparison
Sympathetic nerve stimulation and… vs Unstimulated lung (control condition)
Design
Preclinical
Authors
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Sympathetic effects on feline pulmonary impedance are model-specific; leaves open translation to human RV afterload or PH therapies.
Does sympathetic nerve and alpha-adrenergic stimulation alter pulmonary vascular input impedance and hydraulic power in the cat lung during variations of cardiac output?
Sympathetic and alpha-adrenergic stimulation significantly increases pulmonary vascular resistance and input impedance in the cat lung, with the relative influence on impedance being larger than on resistance.
H. Piene (1976) studied this question.
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