Why the study?
Does sympathetic nerve stimulation and pharmacological modulation affect norepinephrine release in perfused rabbit lungs?
Population
Rabbit lungs perfused via the pulmonary artery
Comparison
Electrical stimulation of sympathetic nerves and… vs Basal state or state without specific…
Design
Preclinical
Authors
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Supports presynaptic inhibition of pulmonary NE release in rabbits; hypothesis-generating for sympathetic regulation in human lung disease.
Does sympathetic nerve stimulation and pharmacological modulation affect norepinephrine release in perfused rabbit lungs?
Sympathetic nerve stimulation increases norepinephrine release in rabbit lungs, which appears to be regulated by muscarinic and PGE-mediated presynaptic inhibitory mechanisms.
Tong et al. (1978) studied this question.
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