October 1, 1971Acta Physiologica Scandinavica
Increased Nerve Stimulation Induced Release of Noradrenaline from the Rabbit Heart after Inhibition of Prostaglandin Synthesis
Key result
Inhibition of prostaglandin synthesis with 5,8,11,14-eicosatetraynoic acid decreased prostaglandin outflow and increased noradrenaline release in response to sympathetic nerve stimulation.
Why the study?
Does 5,8,11,14-eicosatetraynoic acid increase the release of noradrenaline induced by sympathetic nerve stimulation in isolated perfused rabbit hearts?
Population
Isolated perfused rabbit heart
Design
Preclinical
Authors
Discussion
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Implication
Confirms prostaglandin-mediated negative feedback on cardiac noradrenaline release in isolated rabbit hearts; leaves open translation to human physiology.
Structured PICO
Does 5,8,11,14-eicosatetraynoic acid increase the release of noradrenaline induced by sympathetic nerve stimulation in isolated perfused rabbit hearts?
P
Population
Isolated perfused rabbit heart
I
Intervention
5,8,11,14-eicosatetraynoic acid (prostaglandin synthesis inhibitor)
O
Outcome
Release of noradrenaline induced by sympathetic nerve stimulationsurrogate
This study provides conclusive evidence for an endogenous prostaglandin-mediated negative feed-back control mechanism on the release of adrenergic transmitters in the heart.
Cite This Study
Samuelsson et al. (1971) studied this question. 5,8,11,14-eicosatetraynoic acid was evaluated on Release of noradrenaline induced by sympathetic nerve stimulation. Inhibition of prostaglandin synthesis with 5,8,11,14-eicosatetraynoic acid decreased prostaglandin outflow and increased noradrenaline release in response to sympathetic nerve stimulation.