This preclinical study investigated the effects of various pharmacological agents on noradrenaline release and mechanical responses in isolated rabbit hearts during sympathetic nerve stimulation.
Caution against clinical translation from rabbit hearts; leaves open mechanistic hypotheses for sympathetic modulation.
The heart has been used as a convenient tool of physiological and pharmacological studies of nerves and muscles. The present experiment was done in rabbit’s heart as a possible preparation to be isolated with the sympathetic nerve in a convenient experimental animal. At the beginning of the present experiment, investigation was done as to whether or not there was a relationship between positive mechanical responses to and noradrenaline output released by the sympathetic nerve stimulation. Effects of high concentrations of external Ca++ and Mg++, cocaine and adrenergic β-blockers on noradrenaline output released by the sympathetic nerve stimulation were re-investigated.
No takes yet. Share an insight, caveat, or question.
Misu et al. (1972) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: