This preclinical study investigated the pharmacological modulation of noradrenaline release in an isolated rabbit heart model.
Should not change clinical practice; leaves open translation of rabbit heart noradrenaline modulation to humans.
The heart has been used as a convenient tool of physiological and pharmacological studies of nerves and muscles. The present experiment was done in rabbit’s heart as a possible preparation to be isolated with the sympathetic nerve in a convenient experimental animal. At the beginning of the present experiment, investigation was done as to whether or not there was a relationship between positive mechanical responses to and noradrenaline output released by the sympathetic nerve stimulation. Effects of high concentrations of external Ca++ and Mg++, cocaine and adrenergic β-blockers on noradrenaline output released by the sympathetic nerve stimulation were re-investigated.
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Misu et al. (1972) studied this question.
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