Why the study?
Does noradrenaline affect coronary resistance in isolated perfused hearts?
Population
Isolated, perfused hearts of the cat, dog and monkey
Design
Preclinical
Authors
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Noradrenaline's direct vasoconstriction in isolated hearts should not yet guide clinical use; leaves open translation to intact human physiology.
Does noradrenaline affect coronary resistance in isolated perfused hearts?
The direct action of noradrenaline on coronary vessels is vasoconstriction, with vasodilation occurring secondary to myocardial stimulation at higher concentrations.
E. Proctor (1968) studied this question.
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