Key result
Noradrenaline is as effective, and probably more so, than adrenaline in raising the oxygen consumption of the isolated dog heart-lung preparation, with equal chronotropic and coronary dilating actions.
Why the study?
Do adrenaline and noradrenaline have differing effects on metabolism and performance in isolated dog hearts?
Population
16 dog heart-lung preparations modified to permit a more accurate measurement of coronary flow, and 12…
Comparison
Adrenaline or noradrenaline infused at a rate of… vs The other sympathomimetic amine and pre-infusion…
Design
Preclinical
Authors
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May guide noradrenaline selection in cardiogenic shock; leaves open translation from isolated animal preparations.
Do adrenaline and noradrenaline have differing effects on metabolism and performance in isolated dog hearts?
In isolated dog hearts, noradrenaline is at least as effective as adrenaline in raising oxygen consumption and has similar chronotropic and coronary dilating effects, suggesting its benefit in cardiogenic shock may involve positive inotropic action.
Fawaz et al. (1960) studied Isolated dog heart-lung preparations (n=16). Adrenaline and noradrenaline vs. Pre-infusion levels / each other was evaluated on Oxygen consumption, heart rate, and coronary flow. Noradrenaline is as effective, and probably more so, than adrenaline in raising the oxygen consumption of the isolated dog heart-lung preparation, with equal chronotropic and coronary dilating actions.
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