Why the study?
Does intravenous infusion of adrenaline, noradrenaline, lactic acid, or sodium lactate alter hemodynamics and metabolic parameters in unanesthetized rabbits?
Does intravenous infusion of adrenaline, noradrenaline, lactic acid, or sodium lactate alter hemodynamics and metabolic parameters in unanesthetized rabbits?
Adrenaline's vasodilator effect and subsequent increase in cardiac output appear to be mediated by its stimulation of lactic acid production in skeletal muscle.
No takes yet. Share an insight, caveat, or question.
Does not support changes in human hemodynamic management; leaves open whether lactic acid mediates adrenaline-induced vasodilation across species.
Lennart Lundholm (1958) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: