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May 1, 1983Clinical Science

A Comparison of the Bronchodilator and Vasopressor Effects of Exercise Levels of Adrenaline in Man

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Why the study?

Does L-adrenaline infusion at exercise-equivalent levels cause bronchodilation and cardiovascular changes in normal subjects?

Population

6 normal, non-atopic subjects

Comparison

L-adrenaline infusion at two doses at rest vs Placebo

Design

Other

Authors

JWJ. B. WarrenRoyal Society of MedicineNDNeil DaltonNational Health Service

Discussion

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Implication

May inform models of exercise physiology in health; leaves open applicability to patients with airway or cardiac disease.

Structured PICO

Does L-adrenaline infusion at exercise-equivalent levels cause bronchodilation and cardiovascular changes in normal subjects?

P
Population
6 normal, non-atopic subjects
I
Intervention
L-adrenaline infusion at two doses (0.025 micrograms min-1 kg-1 and 0.05 micrograms min-1 kg-1) at rest
C
Comparator
Placebo
O
Outcome
Changes in bronchodilation, plasma glucose, heart rate, and blood pressuresurrogate

Adrenaline at exercise levels causes bronchodilation and glycogenolysis but has marginal cardiovascular effects in normal subjects.

Cite This Study

Warren et al. (1983) studied this question.

synapsesocial.com/papers/6a9e9cff070195defe61e4abhttps://doi.org/10.1042/cs0640475
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Also Consider

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  1. 1The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man1985 · 106 citations
  2. 2Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man1980 · 51 citations
  3. 3Stress Levels of Adrenaline Amplify the Blood Pressure Response to Sympathetic Stimulation1986 · 38 citations
  4. 4CHANGES IN PLASMA NORADRENALINE AND ADRENALINE DURING ISOMETRIC EXERCISE1980 · 25 citations
  5. 5INCREASED PLASMA NORADRENALINE DURING LOW DOSE ADRENALINE INFUSION IN RESTING MAN AND DURING SYMPATHETIC STIMULATION1985 · 25 citations