October 1, 1980European Journal of Clinical Investigation
Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man
Key result
L-adrenaline infusion in normotensive volunteers produced dose-related increases in plasma renin activity, blood glucose, cyclic AMP, and free fatty acids, but minimal cardiovascular effects.
Population
6 normotensive volunteers
Design
Other
Follow-up
1 hour
Authors
Discussion
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Overview
Plasma adrenaline unlikely primary in BP elevation; leaves open its mechanistic role and cautions against plasma levels as release index.
Structured PICO
P
Population
6 normotensive volunteers who received L-adrenaline infusions to assess metabolic effects and kinetics.
I
Intervention
L-adrenaline infusion at escalating doses (0.01, 0.03, 0.05, 0.075, and 0.10 microgram/kg/min, each for 10 min) and a 1-hour infusion at 0.083 +/- 0.006 microgram/kg/min
O
Outcome
Metabolic effects (plasma renin activity, blood glucose, cyclic AMP, free fatty acids) and kinetics (secretion rate, clearance rate) of infused adrenalinesurrogate
Plasma adrenaline is unlikely to be of primary importance in the elevation of blood pressure, and interindividual variation in clearance limits the utility of plasma levels as an index of adrenal release.
Limitations
- Variation in clearance between subjects limits the use of plasma levels as an interindividual index of adrenal release of adrenaline.
- The relationship between sympathoadrenal activity and plasma adrenaline may be perturbed by equilibration between the circulation and sites of tissue uptake.
- Variation in clearance between subjects limits the use of plasma levels as an interindividual index of adrenal release of adrenaline
Cite This Study
FitzGerald et al. (1980) studied Normotensive (n=6). L-adrenaline infusion was evaluated on Metabolic effects and kinetics (plasma adrenaline, secretion rate, clearance). L-adrenaline infusion in normotensive volunteers produced dose-related increases in plasma renin activity, blood glucose, cyclic AMP, and free fatty acids, but minimal cardiovascular effects.