Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 1, 1985Clinical Science

The effect of Adrenaline upon Cardiovascular and Metabolic Functions in Man

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does intravenous adrenaline at physiological concentrations alter cardiovascular and metabolic functions in healthy young men?

Population

7 young healthy male subjects

Comparison

Intravenous adrenaline at 50 ng/min/kg or 10… vs Intravenous sodium chloride solution plus…

Design

Other

Follow-up

30 minutes of infusion and up to 30 minutes post-infusion

Authors

IFI W FellowsSt Bartholomew's HospitalTBT. BennettUniversity of ManchesterIMIan MacdonaldFlorida State University

Discussion

Loading...

Member takes

Implication

May explain persistent post-infusion tachycardia; hypothesis-generating for metabolic mechanisms in clinical populations.

Structured PICO

Does intravenous adrenaline at physiological concentrations alter cardiovascular and metabolic functions in healthy young men?

P
Population
7 young healthy male subjects
I
Intervention
Intravenous adrenaline at 50 ng/min/kg (high dose) or 10 ng/min/kg (low dose) over 30 minutes
C
Comparator
Intravenous sodium chloride solution (saline) plus ascorbic acid (1 mg/ml) over 30 minutes
O
Outcome
Changes in heart rate, blood pressure, vascular resistance, metabolic rate, and blood metabolites (glucose, glycerol, lactate, potassium)surrogate

Physiological concentrations of adrenaline induce significant cardiovascular and metabolic changes, including persistent tachycardia that may be driven by elevated metabolic rate.

Cite This Study

Fellows et al. (1985) studied this question.

synapsesocial.com/papers/6a79adeea861e9f5993242d6https://doi.org/10.1042/cs0690215
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Circulating adrenaline and blood pressure: the metabolic effects and kinetics of infused adrenaline in man1980 · 51 citations
  2. 2Cardiovascular and metabolic responses to low dose adrenaline infusion: an invasive study in humans1986 · 76 citations
  3. 3A Comparison of the Bronchodilator and Vasopressor Effects of Exercise Levels of Adrenaline in Man1983 · 53 citations
  4. 4Metabolic, Electrocardiographic, and Hemodynamic Responses to Increased Circulating Adrenaline: Effects of Selective and Nonselective Beta Adrenoceptor Blockade1990 · 32 citations
  5. 5Adrenaline infusion in man increases muscle sympathetic nerve activity and noradrenaline overflow to plasma1989 · 38 citations