Why the study?
Does selective versus nonselective beta blockade differentially affect hemodynamic, electrocardiographic, and metabolic responses to adrenaline infusion in healthy male volunteers?
Population
12 healthy male volunteers
Comparison
Two days' pretreatment with atenolol… vs Two days' pretreatment with placebo prior to…
Design
RCT, random order
Follow-up
120 minutes
Authors
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Nonselective beta blockers may warrant preference in acute MI; extends RCT evidence on selectivity-dependent protection against catecholamine effects.
Does selective versus nonselective beta blockade differentially affect hemodynamic, electrocardiographic, and metabolic responses to adrenaline infusion in healthy male volunteers?
Nonselective beta blockers may offer superior protection against adrenaline-induced metabolic and electrocardiographic derangements compared to beta-1 selective agents, which may be relevant in the setting of acute myocardial infarction.
Hansen et al. (1990) studied this question.
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